After completing a DEA in Economic and Business Law (Pantheon Sorbonne), Marie-Laure joined Sciences Po Paris. Literary editor of the film production house of Fabienne Servan-Schreiber (Cinétévé), she initiates and develops fiction for TV and cinema and later co-directed the company Télé Images Créations (subsidiary of TéLé Images / Simone Harari).
In 2007, she created with her husband, the ML and JF de Clermont-Tonnerre Foundation, aiming to make education accessible to unprivileged children and teens. In the art field for many years now, this foundation awards a scholarship to a student of the Beaux Arts de Paris (Prix Agnès B) and supports the Zao Wou Ki foundation as well as the french Cinémathèque. In 2008 she was elected to the committee of the society of Friends of the Museum of Art and History in Geneva. In 2013 she was elected to the board of the Tokyo Art Club and the Friends of Palais de Tokyo. The Cartier Foundation invited her to become part of their “Vivre en Couleurs” exclusive circle. In 2012 she published “La médecine personnalisée” (éd.Odile Jacob), after an in-depth investigation in a team of General Doctors. Two more books followed and over 300 000 copies were sold.